PEMBERIAN PROBIOTIK TERHADAP PENINGKATAN KADAR KALSIUM DARAH PADA PASIEN PENYAKIT GINJAL KRONIK TERMINAL

Taufik Maryusman, M Sulchan, Shofa Chasani

Abstract


Patients with Terminal Chronic Renal Disease (ESRD) generally have impaired metabolism of minerals such as calcium. Probiotics can increase the balance of gastrointestinal microflora. Suplementation probiotics may increase levels of calcium. The aim of this study was to analyze the effect of probiotics on the increase of calcium levels. This study used a true experiment research using a randomized pre-post test control group design involving 24 subjects divided into 2 groups at random. The treatment group was given lactobacillus probiotics  (4.0x109CFU) each day in capsul, while the control group was given standard treatment. Statistical analyzes applied paired t-test and independent t-test. Data regarding characteristics of subject were collected using a structured questionnaire. Calcium levels measured by CPO methods and It conducted before intervension and after the intervention. Calcium levels in the treatment group increased at 0.9 g / dl, or higher than in the control group 0.7 g / dl. The treatment group showed a significant increase of calcium level (p = 0.02). But, this increases did not make a significant difference between the 2 groups. Giving of probiotics increases blood calcium levels even in a small level, therefore it is beneficial to be given to patients with ESRD.

ABSTRAK

 

Penderita Penyakit Ginjal Kronik (PGK) terminal pada umumnya mengalami gangguan metabolisme mineral seperti kalsium. Probiotik mampu meningkatkan keseimbangan mikroflora saluran pencernaan. Suplementasi probiotik mampu meningkatkan kadar kalsium. Tujuan penelitian ini adalah menganalisis pengaruh pemberian probiotik terhadap kadar kalsium darah pada pasien PGK terminal. Penelitian ini merupakan penelitian true experiment dengan rancangan randomized pre-post test control group design yang melibatkan 24 subjek yang dibagi menjadi 2 kelompok secara acak. Kelompok perlakuan  diberikan probiotik lactobacillus (4.0x109CFU) per hari dalam bentuk kapsul, sedangkan kelompok kontrol diberikan pengobatan standar. Pengumpulan data penelitian meliputi karakteristik subjek yang dilakukan dengan wawancara menggunakan kuesioner. Data kalsium darah diperoleh dari hasil pemeriksaan dengan metode OCP. Analisis statistik yang dilakukan adalah uji paired t-tes dan independent t-test. Kadar kalsium pada kelompok perlakuan meningkat 0,9 g/dl, atau lebih tinggi dibandingkan pada kelompok kontrol 0,7 g/dl. Kelompok perlakuan menunjukan peningkatan kadar kalsium secara bermakna (p=0,02).  Namun kenaikan ini tidak memberikan perbedaan yang bermakna antara dua kelompok (p= 0,21) Pemberian probiotik meningkatkan kadar kalsium darah walapun tidak banyak, sehingga bermanfaat untuk diberikan kepada pasien PGK terminal.

 

Kata kunci: probiotik lactobacillus, kadar kalsium, PGK terminal




Keywords


lactobacillus probiotics, calcium levels, ESRD

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