STUDI EFFEKTIVITAS KEFIR BENING DAN MENIRAN (Philanthus niruri) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA HEWAN TIKUS WISTAR HIPERGLIKEMIA DIINDUKSI STREPTOZOTOCIN

Judiono ., Soeharyo Hadisaputro, RRJ Djokomoeljanto, Budi Laksono, Theophilus W
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Abstract

EFFECTIVITY STUDY OF PLAIN KEFIR AND MENIRAN (PHILANTUS NIRURI) ON BLOOD GLUCOSE
LEVELS ON HYPERGLYCEMIA WISTAR RATS INDUCED STREPTOZOTOCIN


Traditional medicines and functional foods used for diabetes therapy increased in Indonesia. Bioactive
components play an important role in decreasing blood glucose. The study aims to prove the
effectiveness of plain kefir and Meniran (Philanthus niruri) to decrease blood glucose levels in wistar rats
with streptozotocin-induced hyperglycemia. The study design was randomized pre – post test control
group. A number of 60 male rats aged 2.5-3 months, 150-250 g were made hyperglycemia by induced
streptozotocin (STZ) 40 mg / kg berat badan. The hyperglycemic rats were grouped into: (1) treated with
0.76 UI insulin /day, (2) treated with 3.6 mL plain kefir /day, (3) treated 2.7 mL meniran / day, (4) positive
control group of hyperglycemic rats, and (5) negative control group (standard diet ad libitum). The rats
were given feed refers to the AIN 93. Fasting glucose levels before and after treatment were measured by
Super (Glucocard II) enzimatic method. The results showed that body weight increased in all treatments,
except meniran, however the increaments were not differ significantly. Changes in body weight of insulin
group were 13.800 + 16.104 g, kefir treatment amounted to 13.812 + 21.294, and meniran increased about
18.394 + 16.225. Changes in blood glucose in the insulin group about -118.571+55.815 mg/dL, kefir
treatment at -102.875+60.454, while meniran group -66,625+37,784. In contrast, the positive control group
tended to increase glucose levels. Conclusion In vitro, plain kefir and meniran potentially lowered blood
glucose levels. However, kefir showed lowered glucose level better than meniran. Futher research needs
to study bio- molecular mechanisms of the decline in the future.


Key words: diabetes mellitus, meniran, plain kefir, streptozotocin (STZ), hyperglycemic rat

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